Wednesday, February 29, 2012

In What Time Should Children Be allowed to Play Gaming system

When should children be allowed to play video gaming? It is a difficult question which many mother and father struggle and will apply to many forms of technology (at the. g., TV, computer, cell phones, iPods). Such issues will most likely grow thornier since technology advances and becomes even more ubiquitous.

As a kid, I spent my youth playing video gaming ? from Pong forward. I?ve always the two enjoyed and been interested in video gaming. I even performed my dissertation research on the effects of video game violence on kids. Thus, I have a lot of understanding of this topic considering the fact that I?m a life-long game lover, a psychologist that has researched their particular effects, and, right now, a mother or father of two boys.

First off, video gaming are not inherently good or awful ? they?re merely a medium, like TV, books, the net, and so on. They shouldn?t be categorically vilified. Just like movies and books, you will find games that educate and enlighten and you will find games that pander to your primitive desire for sex and violence. There is very little research on the effects of video gaming on babies and toddlers, and that research is usually correlational as it would unethical to randomly give 2-year-olds to either playing video gaming 2 hours daily or none at all. Exposing kids to violent video gaming included in a study experiment is usually, needless to say, unthinkable. Nonetheless, I have been aware of very small children, also infants, exposure to games such as Call involving Duty, Grand Theft Auto, and Halo. I know for a undeniable fact that some kids who are only age a few are also playing these kinds of games.

TV, Video gaming, and ADD/ADHD

The brains of young children are creating rapidly and there is some research to claim that contact with highly revitalizing media, such as TV, might ?wire? the brains of young children in a way that they grow accustomed to intense environments. Such children might become bored and inattentive whenever in less stimulating (or traditional) environments ? like listening to a teacher provide a lecture throughout class. Thus, there is a hypothesis (and some correlational research to aid) that children subjected to TV at younger ages are more likely to be identified as having ADD/ADHD once they become old. If you?ve watched some of those Baby Einstein videos, guess what happens I mean! The correlational obtaining between TV viewing from young ages and ADD/ADHD may likely apply to video gaming as well.

Video gaming as a procera avh?

Looking at things from the different viewpoint, the study on neuroplasticity indicates that the brain in fact is just like a muscle because it can grow in response to stimuli. Video gaming contain rich environments with a lot of complex cognitive challenges that provide brains a significant workout. There?s a growing human body of research to aid that video game play enhances cognitive functioning in several areas. Video gaming are listed together of 6 known ?procera avh? in the Feb/Mar 2009 issue of Scientific American Mind. Indeed, Microsoft is looking into the educational great things about typical video gaming.

On a related be aware, if I have to choose from my child watching Dan & Jerry or playing Excellent Mario Universe, I encourage him to play a video game because I think is really a better workout for his or her brain compared to passive connection with TV viewing. Considering the fact that I spent my youth playing video gaming, playing video gaming with my personal oldest son is a huge dream come true in lots of ways. But it?s also a Pandora?s Container. If i left it all around him, however play video gaming until that he passed out of exhaustion. Wanting to set restrictions with him or her on gaming can often be difficult. My own biggest problem now?s that his 2-year-old brother wants to participate in the entertaining, and it is even more complicated to keep him far from the tv . As mother and father of two or more kids know, it?s better to set limits with the first child. Younger siblings always wish to accomplish what your government or sister does.

A few Practical Guidelines

There?s no clear answer to the problem of you ought to allow the kids to play video gaming, but I would say it is better to err on the safe side with limited contact with various forms of electronic press at quite young ages (below 3) with gradually more access as children grow older. Also then, you ought to monitor and limit your children?s exposure and check to make sure that this content is suitable. The Entertainment Software Rating Panel (online world. esrb. org) is a good resource for that.

I think video gaming, like TV, should be seen as a privilege rather than the right. Thus, children can get their limited use of games (and TV) only after they?ve fulfilled various other responsibilities (at the. g., home work, chores). Furthermore, you should consider establishing a good aggregate ?media time? limit in a way that TV, the computer (with regard to recreation), and video gaming all come under one limit. Within the period cap (at the. g., one hour daily), kids can make a firm decision how they would like to divvy up their moment.

Perhaps most importantly, you ought to try to serve of the same quality role model for the children. If you?re trying to limit your child?s online game time, however you are always in your laptop, watch a lot of TV or maintain it on for background noise, or play a lot of video gaming yourself, what would you expect your youngster will need? However, if you?re active throughout sports, go throw the ball with your kids, have many hobbies, read a whole lot, and so on, it will send a robust message to your kids. Children often adopt the values of the parents once and for all or awful. When you?re mindful of that and setting one example, you will likely help your youngster stick to a route for personal and academic success.

Austin Counseling might help you or your youngster overcome difficulties in every area of your life. If you?re in Austin, head over to ApaCenter and have a mental health professional assist you to discover opportunities for growth and change.

Source: http://www.blogpostinggroup.com/2012/02/29/in-what-time-should-children-be-allowed-to-play-gaming-system/

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Portman has wedding ring, but is she married?

Natalie Portman, left and Benjamin Millepied arrive at the Vanity Fair Oscar party on Sunday, Feb. 26 in West Hollywood, Calif.

By Us Weekly

Introducing Mr. and Mrs. Millepied! As suspected, Natalie Portman and Benjamin Millepied were indeed sporting wedding bands when they attended Sunday's Academy Awards in Hollywood, jeweler Jaime Wolf confirms to Us Weekly.

PHOTOS: Natalie's gorgeous pregnancy

"I designed the rings worn by Benjamin Millepied and Natalie Portman," Wolf tells Us. "They were made with recycled platinum and conflict free diamonds."

No further details on when or where the actress, 30, and dancer-choreographer, 34, tied the knot. Portman's rep and manager did not reply to requests for comment from Us.

PHOTOS: Natalie's romantic history

After falling in love on the set of "Black Swan," Portman and Millepied announced in late December 2010 that they were engaged and expecting. Millepied was Portman's constant companion on the 2011 awards circuit, where she picked up a bevy of statues (including the Best Actress Oscar) for her portrayal in "Black Swan."

The resolutely private -- but affectionate! -- couple returned at the 2012 Academy Awards, and quietly debuted new wedding bands.

PHOTOS: The newlyweds hit the Oscar afterparties

During her emotional 2011 Oscar speech, Portman called the Frenchman "my beautiful love" and thanked him for giving her "my most important role of my life." They welcomed son Aleph in June 2010.

A "Black Swan" set source told Us it was "seductive to watch" Portman and Millepied fall for one another. "There was no way the attraction could be missed. I don't think he could help himself -- she's dazzling!"

Related content:

Source: http://todayentertainment.today.msnbc.msn.com/_news/2012/02/28/10530025-natalie-portman-benjamin-millepied-are-in-fact-married

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Tuesday, February 28, 2012

Why You Will Want Precautionary Pet Meds In Your Beloved ...

[unable to retrieve full-text content]Chop up the medicines for a pet horses, and mix it with the granules with many molasses to have the blend along. Get immediate results for one's four-legged companion using this amazing paste. However you will get your pet your own ...

Source: http://cladea2010.org/?p=2650

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Monday, February 27, 2012

Everything old was new again at the Oscars (AP)

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Oscar host Billy Crystal talks on stage at the 84th Academy Awards in Hollywood, California, February 26, 2012. REUTERS/Gary HershornAP - Justin Bieber wasn't mincing words. "I'm here to bring you the 18 to 24-year-old demographic," the teen pop star told Billy Crystal in the opening Oscar montage. "So, how long do you want me to stay here for?"


Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/ap/20120227/ap_on_en_mo/us_oscars

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Pakistan razes bin Laden's home, erasing memories (AP)

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A girl walks past the building where al Qaeda leader Osama bin Laden was killed by U.S. special forces last May while demolition work is carried out in Abbottabad February 26, 2012.  Pakistani forces began demolishing the house in an unexplained move carried out in the dark of night.  REUTERS/Faisal Mahmood   (PAKISTAN - Tags: POLITICS)AP - Pakistan pushed ahead Sunday with its surprise demolition of the compound where U.S. commandos killed Osama bin Laden last year, likely an attempt to erase the symbol of the colossal security failure that humiliated the nation and severely damaged ties with Washington.


Source: http://us.rd.yahoo.com/dailynews/rss/asia/*http%3A//news.yahoo.com/s/ap/20120226/ap_on_re_as/as_pakistan

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Sunday, February 26, 2012

How to Improve Your English Speaking Skills?

Speaking English puts many foreigners in a tough task. Although you are good at other skills, such as writing and reading, you still get bad results in speaking. How to improve this thing? This article shows you the way of increasing speaking ability.

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How can I improve my English speaking skills?

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1) Targets ? Set yourself five words a day to practice speaking. Keep a log of words that you are going to master and review them regularly. Learn both the meaning and the pronunciation. Try to practice the words with a native speaker, so any corrections can be made to the pronunciation if it is incorrect.

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2) Listen ? Pay close attention to how English words are spoken. Listen to English songs, watch English movies and TV as often as possible. These activities will help you get familiar with the sounds that you need to replicate.

You will be exposed to an array of different accents and get used to how native speakers talk.

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3) Talk ? Seek out people to talk to using the words that you have learned. When you speak try and be as clear as you can, talk slowly so as not to run over your words and help others to understand what you are saying.

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4) Patience ? Don?t be too hard on yourself. Learning a new language is not easy and there will be times when you cannot remember words and make mistakes. Stay calm and be patient with yourself if you forget a word, use an alternative word if there is one or allow the person you are talking to help you out.

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5) Read ? Read as many books and articles you can find. Read them out loud and to a native speaker if possible.

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6) Friends ? Make friends with as many native English speakers you can find.

Let them know you are trying to learn to speak Englsih well and take the opportunity to chat when you can as this will rapidly increase your speaking skills.

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Peter enjoys writing articles about many different subjects. Come and visit his latest website over at http://panoramicdigitalcameras.com/ which helps people find the best Panoramic Digital Cameras and http://panoramicdigitalcameras.com/digital-underwater-photography/ for information about digital underwater photography.

Source: http://www.a1article.net/writing-speaking/how-to-improve-your-english-speaking-skills-5155.html

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The Certainty Concerning The search engines Black color Book

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Source: http://rocklandnc.com/the-certainty-concerning-the-search-engines-black-color-book/1552/

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Saturday, February 25, 2012

Get Your Online Real Estate In Order To Make You A Ton Of Cash

For many folks, the reason they start marketing online is simply because they want some extra income or have that dream of quitting their jobs. There?s no doubt that the internet has provided opportunities for men and women that can result in more freedom and a better quality of life. The primary way that this happens is through the building of passive income streams and nobody doubts that the notion of being able to earn while you sleep has always been something individuals dream of. Needless to say, you may not know that when you start to construct your web based business, you are creating an asset that has honest value. One way you are able to make money quite quickly on the web is by selling this virtual real estate for nice lump sum income. Here are a few of the items you are able to do to make it happen for yourself.

The initial thing we need to look at is domain names and why they?re able to be sold for loads of cash. The early years of the web saw folks with foresight grab some very valuable domains and those domains will only be available again at an enormous price. Obviously, however, the world of domain name purchasing and selling is quite active and there is quite loads of cash to be made. The reason why this is true is that keyword domains can be very attractive to some specific buyers and jumping on trending types of domain names that haven?t yet been purchased is also a good idea.

Loads of domains get dropped every single day and if you understand where to look there is quite a lot of value to be had. Additionally, although good dot coms are most likely the most difficult to find available from new you can find other extensions for instance dot net and dot org. There is real value to be realized in country code domain names and a few markets still have them open to buyers. The next stage in virtual real estate success is to actually put an internet site up on the domain names that you have invested in.

Loads of potential value is included on a domain name that has a site created on top of it, even when that site is merely a self hosted wordpress blog. Surprisingly, there?s a market for brand new websites that have been built in good niches and there are buyers who would like to snap them up. Obviously, if you actually take some time to develop the site, earn some revenue through it and get a good traffic flow, you?ll have the ability to get quite considerably more leverage and more cash through the sale. When you go to auction sites like Flippa, you?ll see the sort of prices that a number of these sites are being sold for. As you become more experienced you may possibly even see sites you wish to invest in that are under monetized. These could after that be built up by you and flipped for a big profit.

Virtual real estate is actually like selling any other type of property in as much as the price will be based on the interest in what you own. If you do some research, you will get a better idea of how to properly target your own efforts for the best sorts of website and domain product sales. In the long run, selling sites and domains can be a nice technique to get quick lump sum payouts which can supplement whatever other business you do on the net.

For more information on having your blog increase real estate revenue check out my renegade millionaire bonus blog.

Source: http://internetbasedbusinessarticles.com/123591/get-your-online-real-estate-in-order-to-make-you-a-ton-of-cash/?utm_source=rss&utm_medium=rss&utm_campaign=get-your-online-real-estate-in-order-to-make-you-a-ton-of-cash

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Friday, February 24, 2012

Man United loses in Europa League but progresses

updated 5:25 p.m. ET Feb. 23, 2012

LONDON - Manchester United reached the next round of the Europa League despite losing 2-1 to Ajax on Thursday for its first home defeat in the competition.

United entered the game with a 2-0 lead from the first leg. The English power advanced 3-2 on total goals.

United will face Atletic Bilbao in the round of 16 after the Spanish club beat Lokomotiv Moscow 1-0 to advance on away goals. Also progressing were Valencia, Atletico Madrid, PSV Eindhoven and Udinese.

Javier Hernandez opened the scoring for United in the sixth minute and Aras Ozbiliz tied it 31 minutes later. Toby Alderweireld scored with three minutes left, but Ajax could do no more than scare United.

United is in the second-tier tournament after it was eliminated from the Champions League group stage.

Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Source: http://nbcsports.msnbc.com/id/46504186/ns/sports-soccer/

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Proview Thwarted In Chinese iPad Trademark Suit, Brings Case To U.S. Shores

chinapple2The dispute between Apple and Proview over the "iPad" trademark has just gotten a lot more domestic. Proview, which owned the "iPad" trademark in several countries until they sold the rights to Apple, has been alleging shenanigans, specifically that part of the company never authorized the sale. Apple, for their part, says that everything is in order, and they have the signatures of the recalcitrant Shenzhen branch of Proview to prove it. A Chinese court found that while the ownership of the trademark was not yet able to be settled, there wasn't enough evidence to support a sales ban on the iPad. But now Proview has brought the court to California, alleging that Apple defrauded them of the trademark by approaching them as a fictional company: IP Application Development Ltd. — IPAD Ltd.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/MxOO_NqcVE4/

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Thursday, February 23, 2012

World of Warcraft boosts cognitive functioning in some older adults

Wednesday, February 22, 2012

For some older adults, the online video game World of Warcraft (WoW) may provide more than just an opportunity for escapist adventure. Researchers from North Carolina State University have found that playing WoW actually boosted cognitive functioning for older adults ? particularly those adults who had scored poorly on cognitive ability tests before playing the game.

"We chose World of Warcraft because it has attributes we felt may produce benefits ? it is a cognitively challenging game in a socially interactive environment that presents users with novel situations," says Dr. Anne McLaughlin, an assistant professor of psychology at NC State and co-author of a paper on the study. "We found there were improvements, but it depended on each participant's baseline cognitive functioning level."

Researchers from NC State's Gains Through Gaming laboratory first tested the cognitive functioning of study participants, aged 60 to 77, to set a baseline. The researchers looked at cognitive abilities including spatial ability, memory and how well participants could focus their attention.

An "experimental" group of study participants then played WoW on their home computers for approximately 14 hours over the course of two weeks, before being re-tested. A "control" group of study participants did not play WoW, but were also re-tested after two weeks.

Comparing the cognitive functioning test scores of participants in the experimental and control groups, the researchers found the group that played WoW saw a much greater increase in cognitive functioning, though the effect varied according to each participant's baseline score.

"Among participants who scored well on baseline cognitive functioning tests, there was no significant improvement after playing WoW ? they were already doing great," McLaughlin says. "But we saw significant improvement in both spatial ability and focus for participants who scored low on the initial baseline tests." Pre- and post-game testing showed no change for participants on memory.

"The people who needed it most ? those who performed the worst on the initial testing ? saw the most improvement," says Dr. Jason Allaire, an associate professor of psychology at NC State and co-author of a paper on the study.

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The paper, "Individual differences in response to cognitive training: Using a multi-modal, attentionally demanding game-based intervention for older adults," is published online in Computers in Human Behavior.

North Carolina State University: http://www.ncsu.edu

Thanks to North Carolina State University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/117804/World_of_Warcraft_boosts_cognitive_functioning_in_some_older_adults

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Begin job ? Article Directory ? Unique History of Coffee

Coffee is becoming named a human requirement. It is consumed worldwide by all amounts of culture, the prosperous, the center school, along with the inadequate alike.

Star has this that coffee was initially identified by a great Arab goat-herder referred to as Kaldi who, within approximately AD 850, pointed out that his or her flock regarding goats has been behaving in the unusual way soon after feeding about the fruits growing on the particular evergreen rose bush. Not undesirable to personal testing, Kaldi tasted your beans, or even berries, noticed the ?kick? these people produced, as well as proceeded straight away to inform anyone about their discovery. This specific story is obviously incorrect, yet consists of several cereals of reality. Notably the hero of the account is definitely an Arab because the 1st peoples in order to trade inside coffee and propagate its fame on the Middle East all together were Arabs. Coffea arabica, one of many 2 major types of coffee beans (another becoming the Robusta vegetable), was probably the initial type of coffee to get cultivated. Grown in Arabia for more than 15 centuries, it can be believed to produce better coffee than other over the counter grown coffee bean.

Today the majority of coffee lovers report that Arabica coffee beans make the many flavorful as well as aromatic makes, thus causing them to be the actual gourmet espresso beans around the globe.

What is noted for a truth is that coffee increasing and consuming began within the Horn associated with Africa, most likely inside the in the Ethiopian domain of Kaffa from which, according to tale, coffee gets the name. At first coffee coffee beans, or ?coffee cherries? while they maintained, were used because food for slaves. The pinto beans followed slaves in the Sudan straight into Yemen and additional in to the Arabian Peninsula, entering with the port city of Mocha. The particular beans were cultivated within Yemen, probably because the 1500s, nevertheless it has been Dutch traders who at the outset of your 17th one hundred year first released coffee plants on the Netherlands. The Nederlander grew your plants inside greenhouses. Under a century later, we were holding increasing coffee beans upon plantations in the particular East along with West Indies, together become the primary suppliers associated with coffee to European countries. Later they will exported coffee growing to Central and South America.

The British founded coffee in Jamaica in about 1730. Today the most famous and expensive coffee on the planet is actually grown inside island?s Blue Mountains place.

The initial mention of the coffee consuming in America originates from 1668, and very soon right after coffee houses have been established in major United states cities which include Boston, Nyc, and also Philadelphia. The thought to the Birkenstock boston Tea Social gathering was born and organized in Boston?s Green Dragon coffee residence. And, well-known American institutions such as the Nyse as well as the Financial institution of the latest York were commenced in coffeehouses of what will be today named Wall Street.

Yet in the past, no meals or drink may be as strongly condemned by arranged authority, since has coffee. Through the age range, it is often attributed for mixing up riots, motivating seditious speech and promoting Devil worship. During the 1500s, the actual ruler of Constantinople forbade drinking coffee. Even in Cairo as well as Mecca, imbibers also experienced prohibitions. And in Turkey, following a second offense, individuals caught taking the proscribed refreshment were supposedly sewn directly into leather hand bags and heaved in to the ocean!

Needless to say, coffee consuming prevailed, and today coffee is among the many consumed drinks on the planet. The highest per-capita coffee drinkers on earth will be the Scandinavians, as well as the particular Finnish, where an average of individuals drink over four cups of coffee a day. Inside Oughout.S., more than half of all Us citizens older than Eighteen drink coffee on a regular basis, calculating three . 5 cups a day each. In ?09 the common American consumed 416 8-ounce servings of coffee.

Thankfully, medical research now ascribes particular health advantages for you to moderate coffee ingestion including protection against diabetes type 2, reduced risk for many malignancies, heart beat problems, as well as strokes, Parkinson?s illness, and dementia. Additionally, the most up-to-date studies suggest moderate coffee drinking is able to reduce despression symptoms in ladies, reduced potential risk of fatal cancer of the prostate in men, along with control Alzheimer?s disease.

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Source: http://beginjob.com/food-and-drink/unique-history-of-coffee.html

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Wednesday, February 22, 2012

California gay-marriage opponents launch a legal gambit - latimes ...

Gaymarriage2

In deciding to ask a federal appeals court to reconsider the ruling against Proposition 8, backers of the ballot measure that banned same-sex marriage in California are gambling on the possibility that a more conservative panel of judges would issue a broader ruling in favor of such bans, legal scholars said Tuesday.

?They don?t have much to lose," UC Davis Law professor Vikram Amar said. ?If they get a bunch of conservatives on the panel, they win.?

ProtectMarriage, sponsor of Proposition 8, the gay marriage ban overturned by the 2-1 decision, said it would ask the U.S. 9th Circuit Court of Appeals to rehear the case "en banc." An en banc panel in the 9th Circuit would consist of Chief Judge Alex Kozinski, a Republican appointee with libertarian leanings, and 10 other judges chosen randomly.

Legal scholars predicted a close vote within the 9th Circuit on whether to grant such a review, which is relatively rare. If granted, en banc review could delay the case from reaching the U.S. Supreme Court for at least several months, possibly more than a year.

Loyola Law School professor Douglas NeJaime said an en banc panel could reframe the case more broadly. A ruling that grants gays new constitutional rights and affects the entire country is more likely to be overturned by the high court than a narrow decision, he said.

The Feb. 7 decision was written narrowly and limited only to California. It was based on a 1996 U.S. Supreme Court ruling that prevents a majority from taking away a minority?s rights for no legitimate reason.

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-- Maura Dolan

Photo: Protesters rally outside the San Francisco courthouse in June as the Proposition 8 battle was being waged inside. Credit: Justin Sullivan / Getty Images

Source: http://latimesblogs.latimes.com/lanow/2012/02/california-gay-marriage-opponents-taking-a-legal-gambit-.html

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Tuesday, February 21, 2012

A Look At Simple Plans Of Home Improvement - Craft Christmas ...

Feb 21, 2012 by RumfeltStange142

When it comes to the place you live, you want to make it as comfortable and beautiful as you can. The ideal way to ensure your that your home is a s good as it can be is to learn as much as you can about home improvement, and do it yourself. This article should help you learn some tips on ways to improve your house.

A great tip for any do it yourself home improvement homeowner is to take some classes at your local home improvement store. The big home improvement stores want your business, so they offer classes on how to do everything from painting walls, to installing tile floors. Take some classes and learn the basics before you dive into your next home improvement project.

Whenever you are moving or doing a home improvement project, do not forget to take the time to protect your floors. Shuffling equipment and fixtures around during a remodel can create a lot of debris and make a big mess on the carpet. Moving appliances and furniture across a room can really scratch up a beautiful hardwood floor. Be sure to cover the floors before you begin.

Reuse as much as possible during your home improvement to save money and help the environment. If you can paint your cabinets to give them a new look, why not? Replace the knobs or handles on them as well to modernize their look. Consider painting tile instead of replacing it to freshen a room.

Since it seems your kitchen is the gathering place for family and friends, then this is the number one renovation most homeowners should consider first, and one that adds the most value to your home. Be sure to go with plenty of cabinet and counter space. Also, no matter the finish on your appliances, just make sure they all coordinate with one another.

Hose down your home on the outside using a pressure washer and detergents made specifically for your siding. Pressure washers can be rented quite economically and they do wonders in cleaning the girt off the outside of your home. Be careful around the roof line and windows. You don?t want to knock anything loose!

Fix up the entrance to your house by giving it a new coat of paint and a new welcome mat. Your entrance plays an important role in how you welcome your guests into your home. Extra touches like an attractive welcome mat and a pretty potted plant by your entrance will create a positive impression on your visitors.

As presented above, using just a few simple tips, you can increase the value of your home and remodel without having to worry about losing money. When it comes time to sell, you will be glad that your house stands out above the rest with the right improvements that will ensure a quick and profitable sale.

Look at our website for great guidance? landscape wallpapers & considering Postcard Printing Company.

Source: http://www.craftchristmas.com/a-look-at-simple-plans-of-home-improvement_1689.html

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Continuing Education is A Way to Look to the Future - Free Content ...

It is often said that education is the key to success. In the past, those who could not attend post-secondary school for a variety of reasons didn?t have many options. That is until Continuing Education programs became popular and opened up doors. Today, continuing education is similar to adult education, at least in being intended for adult learners. However, it is not normally considered to include basic instruction such as literacy, English language skills or programs such as vocational training or GED preparation. Instead, as the term suggests, it is assumed that the student already has an education and is simply continuing it. In Canada, Continuing Education involves enrollment in college/university credit-granting courses, often by students enrolled part-time.

One such Canadian institution to offer a Continuing Education option is Centennial College, which has nearly 22,000 learners each year in 160 programs that feature more than 1,200 courses and a 97 per cent learner satisfaction. This school?s programs are designed to help students improve their skills, further their education, pursue a variety of interests and enable them to embrace new possibilities. In addition, the Continuing Education school at Centennial College provides experienced instructors who understand adult learning needs, offering flexible, learner-centered teaching methodologies; provides practical hands-on knowledge to place relevant theory into context and perspective; recognizes and respects both the level of maturity and work experience of its students; provides effective instructor to student ratio and an optimal classroom size enabling competent peer interaction.

Areas of Continuing Education study include: Addiction Studies, Business, Computers and Information Technology, Early Childhood Education, Engineering Technology, Food Service Worker, Media and Design, Part-time Health Studies, Retirement Communities Management/Long Term Care Management, Transportation, and more.

All programs facilitated through the continuing education school have their own prerequisites and it?s best to check each individual program?s page to ensure that students have the necessary requirements to apply. It should also be noted that within certain programs there might be qualification requirements and costs for external accreditations, designations, certifications or recognitions. These are set by the granting bodies and not by Centennial College. In order to qualify for any of those external accreditations, designations, certification or recognition, students and graduates will need to follow the processes and meet the applicable requirements listed on the websites and materials of those external bodies.

In addition, those students who can?t make it to campus but wish to attend the Continuing Education School can choose the Distance Learning option, which is conducted entirely online. This study option still allows students to enjoy similar in-person benefits of a physical classroom such as: a qualified and industry-experienced instructor, communication tools, discussion boards and forums, a sense of email access with their classmates, digital assignment capability, and more.

Source: http://articlesblogs.info/reference-education/college-university/continuing-education-is-a-way-to-look-to-the-future/

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FSBO Site Founder Reaches Out to Real Estate Pros | Homes For ...

Sorry, Readability was unable to parse this page for content.

Source: http://www.homesforsaleraleigh.com/real-estate-news/fsbo-site-founder-reaches-out-to-real-estate-pros/

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Monday, February 20, 2012

A Brief Guide To Home Party Business Management | Pete ...

Home party business owners are entrepreneurs who have invested a small amount into joining forces with a direct sales program, wherein they provide their wares to individuals on a person-to-person basis. Generally participants will locate individuals who are open to allowing guests to come into their home for demonstrations during a party type event. The people who offer their home up for the party are generally rewarded with free or discounted merchandise for their trouble.

Several common products are sold through programs like this. Items sold include everything form flameless candles to designer storage bowls for the kitchen. Those who do the selling offer items for about 30-50% more than what they pay for them, which will allow them to make a handsome profit in some cases. What really makes this work difficult for some is a lack of a cohesive schedule or a boss to tell them when and how to work; in other words, the freedom can be overwhelming.

The first order of business when it comes to self-employment is finding a designated place to work, even if it is only the corner of your living room. Despite the fact that a lot of this work will be completed on site, there is still a good deal of desk work involved. The possession of a tranquil area to work within the home, allows the self-employed to more easily separate their work and home life from one another.

Along with the necessity for a clearly designated space, a clear schedule is also an important factor in developing consistency and structure. Select specific days and hours that you?ll make yourself available for parties, visit with repeat customers, promote your product, or answer emails. This is a requirement for a structured existence and it can help to keep life events from interfering with work or vice versa.

As you prepare to hunt down people who are open to hosting parties, be willing to try many things. Going to related locations and dropping off business cards or flyers is a good way to drum up some business. It?s not difficult to get people to come to a party, especially when you are offering them free samples of some of their favorite products.

Those who are interested in opening a home party business will find that they have an unlimited variety of choices when it comes to products. Many people have been able to develop a successful home business following this protocol.

If you are looking for more details about this topic then click on Home Party Business and you can also visit American Girl Doll Furniture.

Source: http://www.petebenevides.org/business-2/a-brief-guide-to-home-party-business-management/

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Sunday, February 19, 2012

Ali smiles as Wonder, others sing Happy Birthday

Former boxer Chuck Wepner arrives at the Keep Memory Alive 16th Annual "Power of Love Gala" honoring Muhammad Ali with his 70th birthday celebration on Saturday, Feb. 18, 2012, in Las Vegas. (AP Photo/Jeff Bottari)

Former boxer Chuck Wepner arrives at the Keep Memory Alive 16th Annual "Power of Love Gala" honoring Muhammad Ali with his 70th birthday celebration on Saturday, Feb. 18, 2012, in Las Vegas. (AP Photo/Jeff Bottari)

Actor Tony Danza, television personality Larry King and sportscaster Charley Steiner arrive at the Keep Memory Alive 16th Annual "Power of Love Gala" honoring Muhammad Ali with his 70th birthday celebration on Saturday, Feb. 18, 2012, in Las Vegas. (AP Photo/Jeff Bottari)

Television personality Larry King arrives at the Keep Memory Alive 16th Annual "Power of Love Gala" honoring Muhammad Ali with his 70th birthday celebration on Saturday, Feb. 18, 2012, in Las Vegas. (AP Photo/Jeff Bottari)

Actor Tony Danza arrives at the Keep Memory Alive 16th Annual "Power of Love Gala" honoring Muhammad Ali with his 70th birthday celebration on Saturday, Feb. 18, 2012, in Las Vegas. (AP Photo/Jeff Bottari)

Musician Chris Isaak arrives at the Keep Memory Alive 16th Annual "Power of Love Gala" honoring Muhammad Ali with his 70th birthday celebration on Saturday, Feb. 18, 2012, in Las Vegas. (AP Photo/Jeff Bottari)

(AP) ? A casino owner paid more than a million dollars for boxing gloves Muhammad Ali used to defend his title. Samuel L. Jackson dedicated a rendition of "Stand By Me" to the boxer. And President Barack Obama told the icon in a birthday tribute that he inspired the world.

By the end of the night, all Ali needed to do to capture the hearts of 2,000 revelers in Las Vegas Saturday was go onstage and smile.

Ali sat next to Stevie Wonder, who played keyboards and sang his version of "Happy Birthday," while stars including Sean "Diddy" Combs, Kelly Rowland, LL Cool J, Quincy Jones, Sugar Ray Leonard and boxing promoter Bob Arum followed along.

Combs pinched Ali's cheeks and whispered in his ear, then closed out the nearly 5-hour gala by professing his deep admiration for the fighter.

Ali's eyes widened. He pointed at Combs, then back at his own head, twirling his index finger as if to tell Combs he's crazy.

"The greatest of all time," Combs said after leading the crowd in shouting "Happy birthday, Ali."

The moment closed out the celebration of Ali's life and fundraiser to generate millions of dollars for brain research, a mission Ali's family says is important to him in part because of his nearly 30-year battle with Parkinson's disease.

"Happy birthday, champ," Obama told Ali through a video message, saying he wished he could have attended a swanky dinner gala in Las Vegas featuring some of the biggest names in sports, film, television and music.

"As a fighter, you were something spectacular," Obama told Ali, who turned 70 last month. "You shocked the world, and you inspired it, too. And even after all the titles and legendary bouts, you're still doing it."

A set of gloves Ali used to defeat Floyd Patterson in 1965 in Las Vegas ? the first heavyweight title fight in Sin City ? sold for $1.1 million. It came with one of the original posters used to promote the fight, which had Muhammad Ali's chosen name as a subscript to Cassius Clay, the name he was born with. When Ali converted to Islam, many people resisted calling him by his new name.

Ali entered the room and sat at a table with his family before bidding began on the gloves.

Lorenzo Fertitta, a casino owner and owner of the Ultimate Fighting Championship, the mixed marital arts league, won the gloves, which organizers had said earlier they hoped would fetch $500,000.

Football great Jim Brown said Ali represents the greatest of America, because at one time people only recognized his athletic ability and didn't like what he had to say. That changed over time, he said.

"America started with slavery and ended up with a black president," Brown said. "Muhammad Ali was a part of that ... a big part."

Ali's wife, Lonnie Ali, told the star-studded crowd that her husband's greatest wish has always been to inspire and help others. She said he feels that his life really began when he retired from the ring.

"Muhammad's gift of inspiration is timeless, and now more relevant than ever," she said after being introduced by music icon Quincy Jones.

Lonnie Ali introduced a video montage of her husband's life, including clips from his work with children.

"People look for miracles, people look for wonders, people expect surprises of all kinds," Ali said in the video. "Yet the greatest wonder, the greatest miracle, the greatest surprise is to be found in one's heart."

Guests arriving on the red carpet included football great Franco Harris, supermodel Cindy Crawford, acting star Jackson, Ali's children and grandchildren and Chuck Wepner, who fought Ali in 1975 for the heavyweight title and lost.

"I would go anywhere in the world for Muhammad Ali's birthday," Wepner said.

One of Ali's daughters, Rasheda Ali, said the gala was a chance for friends, family and A-listers who look up to her father to show their respect for his life and legacy as a humanitarian. In return, she says he'll be honored to see them there.

"He has not left that need to help others," Rasheda Ali said. "That's one of his core values ? his charity and his giving."

The gala ? with tickets starting at $1,500 per plate ? was held at the MGM Grand, the site of most of boxing's major fights the past two decades. Famous faces converged on the 160 tables adjacent to two rings and a stage ? Terrence Howard, David Beckham, Anthony Hopkins, Manny Pacquiao, and Lenny Kravitz, among others. They spoke and performed in tribute to a fighter who went 56-5 in the ring with 37 knockouts and became perhaps the most famous athlete ever because of his personality and willingness to publicly stand up for his beliefs.

"He's done it with guts and grace, with his fists, and with his wits," Jackson said. "He's one of the groundbreaking figures of the generation that helped make the world a more open place when it comes to who we can love, where we can go and what we can do. Thank you, champ."

Wonder, who performed earlier in the day at Whitney Houston's funeral, performed "Keep Our Love Alive" and "Superstition." Rasheda Ali said Wonder was the performer her father was most looking forward to seeing.

Wonder wasn't the only performer.

Snoop Dogg sang a medley of his hits, John Legend, Kravitz, Slash, Kelly Rowland and Cee Lo Green all performed. LL Cool J rapped "Mama Said Knock You Out" as DJ Z-Trip span a remixed version of the song that included Ali audio, including his famous "float like a butterfly, sting like a bee" quote.

Tennis great Andre Agassi said Ali has shown the world that each person has a duty ? regardless of their occupation ? to live for more than him or herself and help others.

"What he did with his platform was unparalleled and the impact he's had as a result, we still feel to this day, which is why we're all out here tonight," Agassi said. "We're grateful to what he's done. He's been a leader ? we're also challenged and charged with a duty of figuring out a way to do more."

Ali has lived with Parkinson's disease for nearly 30 years, a degenerative brain condition that some doctors say can be brought on by punches to the head.

The gala raised funds for the Cleveland Clinic Lou Ruvo Center for Brain Health and the Muhammad Ali Center in Louisville, Ky., a cultural attraction that celebrates Ali's life and pushes educational goals on a wide range of topics for adults and children.

Larry Ruvo, chairman of the clinic's fundraising arm, Keep Memory Alive, said he's not sure whether the fundraiser will exceed its record of $27 million, but he hopes so.

The gala's auction includes some items that only an A-lister or others with incredibly deep pockets could possibly afford. The top item was Ali's gloves that he used to fight Floyd Patterson in 1965, a bout he won by knockout in the 12th round.

"If it's $100, great, $100,000 would be better," Larry King said in trying to drum up bids.

Magician David Copperfield auctioned off a four-night trip to his set of 11 private islands in the Bahamas for $300,000.

A fundraising concert featuring Kravitz, Green, guitarist Slash and others for the general public was planned in the same room Sunday night.

Boxing promoter Bob Arum said during a pre-gala reception Friday night attended by celebrities including Hopkins and Larry King that Ali will go down as one of the most important Americans in history.

"Without Muhammad Ali, there wouldn't have been an Obama," he said. "There wouldn't have been a mixed-race president."

ABC and ESPN plan to air the gala on Feb. 25.

___

Oskar Garcia can be reached on Twitter at http://twitter.com/oskargarcia.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-02-19-Ali%20Gala-Vegas/id-6d9f8ccd8ff247f3852dcaf06a238b8f

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Xi Jinping film deals: Search for a Walt Disney of China?

Vice President Xi Jinping announces two film deals that offer Hollywood more access to China and set up a Chinese joint venture with DreamWorks to boost China's push into animation.

When China's Vice President Xi Jinping departed Los Angeles Friday, he left Hollywood a happier place, having announced deals to allow more Hollywood films into China and establish a joint venture studio between DreamWorks Animation and two Chinese media entities to create movies for the Chinese market.

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The twin agreements will give US movie studios increased access to a huge market. China had agreed to allow 14 3-D and large-format films (IMAX) in each year on top of the 20 let in under a previous long-standing annual cap.?In addition, foreign film companies will now be allowed to recoup 25 percent of the returns on those 34 imports as opposed to the old limit of 13.5 percent to 17.5 percent.

The joint venture may be the more intriguing of the two deals, because it builds on animation ? an American strength and a medium that China is eager to exploit, for political as well as commercial reasons.

After the success of DreamWorks Animation's "Kung Fu Panda 2" last year ? it grossed $95 million in China, more than in the United States ? the studio hopes to tap into the nation's huge and underserved market and then re-export the films. For China, animation is a test balloon in the nation's growing media relationship with the world. Without the sex, gore and contemporary politics Beijing's censors deplore, animation is family-oriented and easily redubbed, making it safe and both importable and exportable, and thus likely to lead the charge in a trans-Pacific race for soft power ? one that Hollywood's currently leading.?

"Family entertainment is naturally less subject to censorship and DreamWorks Animation, especially, knows how to entertain in a way that won't offend its Chinese partners," says Elliot Tong, producer and head of international business at the Tianjin North Film Studio, maker of China's most expensive cartoon feature to date, "Legend of a Rabbit."

While it's far too early to anoint a Walt Disney or Pixar of China, its animators are gaining ground with state protection and a little friendly Hollywood aid.?In 2011, China produced more than 100 animated feature films, two dozen of which made it into theaters where they grossed 300 million yuan ($47 million), nearly twice the pot of gold cartoons reaped in 2010. Estimates point to more than half a million Chinese studying animation and about 20,000 professionals already making a living at it in specially designated animation zones, such as the one in Tianjin, that enjoy government subsidies.?Disney has partnered with Creative Power Entertaining of Guangdong, another such zone in south China, to help overseas promotion of its TV cartoon hit, "Pleasant Goat and Big Big Wolf," which is the most popular animated offering on state-run TV.

Overall movie ticket sales have doubled here over the last two years to just over $2 billion in 2011.

Plenty of obstacles remain, however, before Chinese animators are ready to take on the world. For one, they haven't produced a blockbuster. The 3-D feature "Legend of a Rabbit" cost $12 million to make but grossed only $2.4 million in a limited release last July.?One of DreamWorks's new partners, the Shanghai Media Group (SMG), is pushing a wide release of a 3-D version of the 1961 cartoon feature "The Monkey King ? Uproar in Heaven," despite poor reviews.

Nowadays, SMG has little credibility in cartoon production, industry observers say. It is known instead for live action films with approved messages but thin profits such as director Jia Zhangke's acclaimed "Still Life," about the Three Gorges Dam, or actor Jackie Chan's epic "1911" about the fall of the Qing dynasty. However, Mr. Tong says he's not surprised DreamWorks has partnered with SMG, whose distribution channels are what helped "Pleasant Goat and Big Big Wolf" become such a widespread hit.?

"Two parties to a deal don't have to be equal in every area. It's clear that DreamWorks has the creative edge, but SMG has the distribution network already paved," Tong says. "What's more, they're internationalists." For his part, Tong recently sold "Legend of a Rabbit" to a North American distributor at the Berlin International Film Festival and has a sequel in the works for 2013.

Whereas Japan has long been known for its animation ? from the late-1960s anime TV series "Speed Racer" to Hayao Miyazaki's "Spirited Away," the first anime film to win an Academy Award ??China's animation is virtually unknown overseas. There were no independent animators, only those working for state media until 1992, when five Peking University scholars set up the nation's first independent animation group. Interest is picking up.?

"We're getting more applications, but we still have to train them in-house," says Wu Hanqing, chief executive officer of the company, Vasoon. "China still just doesn't have the animators."

Once DreamWorks Animation sets up shop in Shanghai ? as Oriental DreamWorks ? many of China's animators wonder: Will they employ us or destroy us??

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/P2KC9BkiEXg/Xi-Jinping-film-deals-Search-for-a-Walt-Disney-of-China

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Thursday, February 16, 2012

Greenstart Tightens Focus, Goes After ?Sexy? Cleantech Startups

greenstart-logoGreenstart, the San Francisco-based startup accelerator dedicated to the cleantech industry - and more importantly, to making it "sexy" enough to attract investors - announced its second cadre of of companies this week. This time around, the organization is tightening its focus to concentrate solely on the intersection of I.T. and cleantech, specifically in areas of smart grid, the built environment, consumer services and transportation. It's also being highly selective in terms of the startups accepted into the program. Of the 152 applicants, only five companies got in.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/7ovqEefU2QQ/

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Wednesday, February 15, 2012

Getting The Right Video Game Device Today | Man and Van Moving ...

Exactly true, Technological know-how never ceases to astonish everybody with the great advancements being done every single day. The expansion of technology is far past the ability pf the mind to imagine. Comparing the past 10 years to right now, there are a lot associated with developments and improvements when it comes to technology, that could have seemed impossible then. Before, cellular phones existed only for the benefit of conversation, but today these tools can even be employed for other things such as photo taking, music actively playing, voice recording, etc.

Probably the most anticipated creation that was ever invented by kids and children at heart is the video game. There?s also so many variations of games that can be found in the market. The desire of the individuals to have something to do throughout leisure time prompted other people to conceptualize and finally invent interior electronic games. Video game keeps on innovating and its peripherals and other products used in these games are also being developed and enhanced as period goes by.

Gaming systems are the hardware devices that are being used to play the games. Video games systems are also known as gaming consoles. Consoles, basically, are compatible with any other game which manufacturers reach widen their own market. However, because of the large demand of customers in the market, system makers and software or even game developers tie up to come up with a perfect combination for his or her products to market. There are units though that is universal in the sense that it can play a minimum of all designed games available in the market.

Prior to now, lots of game system developers introduced their own video game systems. These systems have different specifications and also have unique capabilities in the aspect of computer gaming. Plus, every maker has their own unique abilities and design they apply to their product.

Just for this enormity of things to consider, players and consumers are left with just one question within their mind: What will I buy? As well as what is the greatest for me? For a lot of, these queries are so difficult to answer particularly if they do not have sufficient idea of the recording game methods available. Therefore, answering these kinds of questions does not just need asking or talking to others but as well as having your own personal research.

You will discover considerations to take in choosing the best video game console for you. A game system can never be regarded as the very best by any other person except by yourself. Items like video game methods are not directly related to what you would like and what you are satisfied with and never by what they are able to give you, even though specification of a certain device is a big factor for your fulfillment. To help you in choosing the best video game, here are some things you can do in finding as well as choosing the best gaming system:

Determine what you want very first. As stated over, what satisfies you is something that solve these questions . answer. The video game system that you must choose should be something you like and based on how you understand your self as well as your desires, and not simply because it is something which your friend has. Your own friend might have different expectations in a gaming system however it helps if you see theirs first to know if you like it.

Go ahead and take the endeavor seriously. Choosing a video game system is the same as choosing what car you?d want to drive. Check every thing, whether your own prospect gaming system can definitely give you the greatest output, like in the audio, the quality of the video, the game mat, etc.

Find video game consoles on the web. There are plenty of product manufacturers that publish their products on the Internet.

Give some thought to individuals video game systems that are produced by known console makers around the world. This will not only give you the best quality there is, however it can also assist you to adjust anytime these companies help to make improvements using their products. In gaming, match ups is an important factor to consider.

Look at what other points would you like your own video game program to do for you personally. Does it provide add-on peripherals? Game pads should also be comfortable to take care of.

The best gaming systems can be made best only when your expectations are fully met. Selecting such a device is primarily dependent on characteristics that your video game system should possess.

Learn even more related to the subject of movies download, get knowledge at this moment.

Source: http://www.123manandvan.com/movingblog/uncategorized/getting-the-right-video-game-device-today/

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GW researchers reveal digital transcriptome of breast cancer

GW researchers reveal digital transcriptome of breast cancer [ Back to EurekAlert! ] Public release date: 14-Feb-2012
[ | E-mail | Share Share ]

Contact: Anne Banner
abanner@gwu.edu
202-994-2261
George Washington University Medical Center

New research could lead to innovative clues about the biology, diagnosis, and targeted therapies for breast cancer

GW Cancer Research Team in the Department of Biochemistry and Molecular Biology, in the School of Medicine and Health Sciences, published a study that is the first of its kind to use mRNA sequencing to look at the expression of genome, at a unprecedented resolution at the current time, in three types of breast cancer. The study titled, "Transcriptomic landscape of breast cancer through mRNA sequencing," is published in the Feb. 14 edition of the journal, Scientific Reports, a new open access Nature journal for large volume data.

Breast cancer is the leading cause of cancer death among women, accounting for about 23% of the total cancer cases and about 14% of the cancer deaths worldwide. One of current bottlenecks that hinder the translation of the current gene expression signatures for the benefits of patient is the highly heterogeneous nature of the disease. Therefore, one way to move forward is to identify and gain a deeper insight into the transcriptional regulatory machinery elements, which ultimately are responsible for phenotypic changes, for the next major leap in breast cancer genomic research and treatment. And this is exactly, what was done here, said the senior author and Team Leader Rakesh Kumar, Ph.D., of the project.

Using a sample set of 17 patients with three different types of breast cancer, the GW Research Team which also included collaborators from the John Hopkins College of Medicine and Baylor College of Medicine looked at similarities and differences in their gene expression patterns with a goal to identify biologically relevant, therapeutically important sets of targets in breast cancer. The researchers undertook a high throughput study to define comprehensive digital transcriptome and performed extensive comparative analysis of three groups of breast cancer from the total 1.2 billion reads at various levels of the transcriptional process. The comparative transcriptomic analyses illuminated common as well as differentially expressing transcripts between the three breast cancer groups. Further, high numbers of novel and unannotated transcripts, revealing global breast cancer transcriptomic adaptations in all three breast cancers were also identified.

"We are excited to be a part of this new approach to understand breast cancer. For the first time mRNA sequencing of human breast cancer tissues provides knowledge on central transcriptional regulatory elements, demonstrating the unexplored niches that could change the way breast cancer is previously understood," said lead author Jeyanthy Eswaran, PhD, Director of the McCormick Genomic and Proteomic Center in the department.

While most research today is mainly focused on preselected genes, GW's approach used a completely unbiased approach in order to come up with original snapshot of the breast cancer transcriptome. The GW researchers are working to gain a better understanding of the fundamental occurrences orchestrating the events that lead to a patient suffering from breast cancer. While searching for the highly abundant primary transcript groups which, the team identified osteonectin, guanine nucleotide binding protein beta polypeptide 2-like 1, calnexin calreticulin, ferritin L subunit, and beta-2 microglobulin (B2M) as the top five highly abundant primary transcript group in all three breast cancers. The GW research group is now teaming up with other breast cancer researchers to expend and validate some of the key findings of this work.

"From the on-going, follow-up work in the laboratory, it is clear that the significance of this study has implications beyond the current digital transcriptome of breast cancer as team is actively characterizing novel mutations in protein-coding genes and other elements of human genome that might be relevant in breast cancer," said Dr. Kumar. In addition, the work is likely to influence breast cancer genomics, the transcriptional regulation of cancer, and help built new biologic pathways in breast cancer in the coming years.

###

To view the paper in its entirety, visit: http://www.nature.com/srep/2012/120214/srep00264/full/srep00264.html

About the GW School of Medicine and Health Sciences:

Founded in 1825, the GW School of Medicine and Health Sciences (SMHS) was the first medical school in the nation's capital and is the 11th oldest in the country. Working together in our nation's capital, with integrity and resolve, the GW SMHS is committed to improving the health and well-being of our local, national and global communities. http://www.smhs.gwumc.edu



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


GW researchers reveal digital transcriptome of breast cancer [ Back to EurekAlert! ] Public release date: 14-Feb-2012
[ | E-mail | Share Share ]

Contact: Anne Banner
abanner@gwu.edu
202-994-2261
George Washington University Medical Center

New research could lead to innovative clues about the biology, diagnosis, and targeted therapies for breast cancer

GW Cancer Research Team in the Department of Biochemistry and Molecular Biology, in the School of Medicine and Health Sciences, published a study that is the first of its kind to use mRNA sequencing to look at the expression of genome, at a unprecedented resolution at the current time, in three types of breast cancer. The study titled, "Transcriptomic landscape of breast cancer through mRNA sequencing," is published in the Feb. 14 edition of the journal, Scientific Reports, a new open access Nature journal for large volume data.

Breast cancer is the leading cause of cancer death among women, accounting for about 23% of the total cancer cases and about 14% of the cancer deaths worldwide. One of current bottlenecks that hinder the translation of the current gene expression signatures for the benefits of patient is the highly heterogeneous nature of the disease. Therefore, one way to move forward is to identify and gain a deeper insight into the transcriptional regulatory machinery elements, which ultimately are responsible for phenotypic changes, for the next major leap in breast cancer genomic research and treatment. And this is exactly, what was done here, said the senior author and Team Leader Rakesh Kumar, Ph.D., of the project.

Using a sample set of 17 patients with three different types of breast cancer, the GW Research Team which also included collaborators from the John Hopkins College of Medicine and Baylor College of Medicine looked at similarities and differences in their gene expression patterns with a goal to identify biologically relevant, therapeutically important sets of targets in breast cancer. The researchers undertook a high throughput study to define comprehensive digital transcriptome and performed extensive comparative analysis of three groups of breast cancer from the total 1.2 billion reads at various levels of the transcriptional process. The comparative transcriptomic analyses illuminated common as well as differentially expressing transcripts between the three breast cancer groups. Further, high numbers of novel and unannotated transcripts, revealing global breast cancer transcriptomic adaptations in all three breast cancers were also identified.

"We are excited to be a part of this new approach to understand breast cancer. For the first time mRNA sequencing of human breast cancer tissues provides knowledge on central transcriptional regulatory elements, demonstrating the unexplored niches that could change the way breast cancer is previously understood," said lead author Jeyanthy Eswaran, PhD, Director of the McCormick Genomic and Proteomic Center in the department.

While most research today is mainly focused on preselected genes, GW's approach used a completely unbiased approach in order to come up with original snapshot of the breast cancer transcriptome. The GW researchers are working to gain a better understanding of the fundamental occurrences orchestrating the events that lead to a patient suffering from breast cancer. While searching for the highly abundant primary transcript groups which, the team identified osteonectin, guanine nucleotide binding protein beta polypeptide 2-like 1, calnexin calreticulin, ferritin L subunit, and beta-2 microglobulin (B2M) as the top five highly abundant primary transcript group in all three breast cancers. The GW research group is now teaming up with other breast cancer researchers to expend and validate some of the key findings of this work.

"From the on-going, follow-up work in the laboratory, it is clear that the significance of this study has implications beyond the current digital transcriptome of breast cancer as team is actively characterizing novel mutations in protein-coding genes and other elements of human genome that might be relevant in breast cancer," said Dr. Kumar. In addition, the work is likely to influence breast cancer genomics, the transcriptional regulation of cancer, and help built new biologic pathways in breast cancer in the coming years.

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To view the paper in its entirety, visit: http://www.nature.com/srep/2012/120214/srep00264/full/srep00264.html

About the GW School of Medicine and Health Sciences:

Founded in 1825, the GW School of Medicine and Health Sciences (SMHS) was the first medical school in the nation's capital and is the 11th oldest in the country. Working together in our nation's capital, with integrity and resolve, the GW SMHS is committed to improving the health and well-being of our local, national and global communities. http://www.smhs.gwumc.edu



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Source: http://www.eurekalert.org/pub_releases/2012-02/gwum-grr021412.php

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